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Maria De Los Angeles Gomez Morales

Senior Researcher
+39 06 4990 2078
299, Viale Regina Elena
00161 - Rome (Italy)
gomez@iss.it


Curriculum vitae

Biographical Notes

Dr. Gomez Morales has 25 years experience in basic and applied research, in the field of human and animal parasitology. She obtained her PhD from University of Granada (Spain) in 1984 studying the humoral immune response of human and murine trichinellosis. Then she spent almost two years as post-doctoral fellow at the National Institute of Public Health of Bilthoven and in the Department of Immunology of the University of Utrecht (The Netherlands), studying the humoral immune response in different infection models. In 1988 she was appointed as Assistant Professor at the Department of Animal Pathology, University of Murcia (Spain), where she collaborated in training activities aimed to the education of future veterinarians. In 1989 she joined the Laboratory of Parasitology of the Istituto Superiore di Sanità, where she carried out studies on the humoral and cell-mediated immunity to parasitic infections, and on the characterization of the immune response to parasites. She is also involved in diagnostic (preparation and isolation of parasitic antigens and antibodies to be used for diagnostic purposes; standardization of diagnostic procedures) and training activities in animal and human parasitology.
At present she is in charge of the Immunology Section at the CRLP.
She published more than 100 papers on international and national scientific journals.

Bibliography

  1. Pozio E, Gomez Morales MA. The impact of HIV-protease inhibitors on opportunistic parasites. Trends in parasitology 2005;21(2):58-63.
  2. Tosini F, Agnoli A, Mele R, Sacchi L, Corona S, Gomez Morales MA, Pozio E. A new modular protein of Cryptosporidium parvum, with ricin B and LCCL domains, expressed in the sporozoite invasive stage. Molecular and biochemical parasitology 2004;134(1):137-147.
  3. Gomez Morales MA, Mele R, Ludovisi A, Bruschi F, Tosini F, Riganò R, Pozio E. Cryptosporidium parvum-specific CD4 TH1 cells from sensitized donors responding to both fractionated and recombinant antigenic proteins. Infection and immunity 2004;72(3):1306-1310.
  4. Mele R, Gomez Morales MA, Tosini F, Pozio E. Cryptospotidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infection and immunity 2004;72(10):6061-6067.
  5. Mele R, Gomez Morales MA, Tosini F, Pozio E. HIV protease inhibitors reduce cryptosporidium parvum infection in both in vitro and in vivo models. In: Mandarino G, Marella AM, ed. International symposium Non conventional unexpected benefits of protease inhibitors in HAART. Istituto Superiore di Sanità. Rome, October 31, 2003. Abstract book. Roma: Istituto Superiore di Sanità; 2003. (ISTISAN Congressi 03/C4). p.16.
  6. Mele R, Gomez Morales MA, Tosini F, Pozio E. Detection and counting of cryptosporidium parvum in HCT-8 cells by flowcytometry. Parasite 2003;10(4):297-302.
  7. Pozio E, Gomez Morales MA, Dupouy-Camet J. Clinical aspects, diagnosis, and treatment of trichinellosis. Expert review of anti-infective therapy 2003;1(3):471-482.
  8. Mele R, Gomez Morales MA, Tosini F, Pozio E. Indinavir reduces Cryptosporidium parvum infection in both in vitro and in vivo models. International journal for parasitology 2003;33(7):757-764.
  9. Pozio E, Sofronic-Milosavljevic L, Gomez Morales MA, Boireau P, Nöckler K. Evaluation of ELISA and Western blot analysis using three antigens to detect anti-Trichinella IgC in horses. Veterinary parasitology 2002;108(2):163-178.
  10. Mele R, Gomez Morales MA, Pozio E. Expression of FASL, FASR, and BCL-2 apoptotic proteins in Cryptosporidium parvum-infected HCT-8 cells. In: 20. International Congress of Parasitology. Parasitology in a New World. Abstracts; August 4-9, 2002; Vancouver. 2002. p.300.
  11. Gomez Morales MA, Mele R, Tosini F, Bruschi F, Riganò R, Pozio E. Generation and characterisation of Cryptosporidium parvum CD4+ T-cell-lines from C. parvum-immune human donors [abstract]. Parassitologia 2002;44(Suppl. 1):83.
  12. Gomez Morales MA, Pozio E. Humoral and cellular immunity against Cryptosporidium infection. Current drug targets, immune, endocrine & metabolic disorders 2002;2(3):291-301.
  13. Tosini F, Agnoli A, Mele R, Gomez Morales MA, Pozio E. Identification and characterisation of CpSA20, a Cryptosporidium parvum protein homologous to the yeast cell-cycle checkpoint hus 1. In: Biocca E, Corradetti A, Starkoff O, ed. Parassitologia; 11-14 giugno 2002; Grugliasco. Roma: Lombardo Editore; 2002. p.187.
  14. Mele R, Gomez Morales MA, Tosini F, Pozio E. In vitro and in vivo activity of human immunodeficiency virus protease inhibitors against Cryptosporidium parvum. In: 20. International Congress of Parasitology. Parasitology in a New World. Abstracts; August 4-9, 2002; Vancouver. 2002. p.300.
  15. Mele R, Gomez Morales MA, Tosini F, Pozio E. Retroviral protease inhibitors reduce Cryptosporidium parvum infection both in in vitro and in vivo models [proceedings]. Parassitologia 2002;44(Suppl. 1):108.
  16. Casulli A, Gomez Morales MA, Vitelli G, Santagada G, Pozio E. Serodiagnosis of cystic echinococcosis (Echinococcus granulosus) in sheep: a preliminary study. In: Biocca E, Corradetti A, Starkoff O, ed. Parassitologia; 11-14 giugno 2002; Grugliasco. Roma: Lombardo Editore; 2002. p.46.
  17. Pozio E, La Rosa G, Gomez Morales MA. Epidemiology of human and animal Trichinellosis in Italy. Parasite 2001;8(Suppl. 2):S106-S108.
  18. Owen IL, Pozio E, Tamburrini A, Danaya RT, Bruschi F, Gomez Morales MA. Focus of human Trichinellosis in Papua New Guinea. American journal of tropical medicine and hygiene 2001;65(5):553-557.
  19. Sofronic-Milosavljevic L, Pozio E, Patrascu I, Skerovic N, Gomez Morales MA, Gamble HR. Immunodiagnosis of Trichinella infection in the horse. Parasite 2001;8(Suppl. 2):S260-S262.
  20. Gomez Morales MA, Mele R, Sanchez M, Sacchini D, De Giacomo M, Pozio E. Increased CD8+-T-cell expression and a type 2 cytokine pattern during the muscular phase of Trichinella infection in humans. Infection and immunity 2001;70(1):233-239.
  21. Bruschi F, Pozio E, Watanabe N, Gomez Morales MA, Ito M, Huang Y, Binaghi R. Anaphylactic response to parasite antigens: IgE and IgG1 independently induce death in Trichinella-infected mice. International archives of allergy and immunology 1999;119(4):291-296.
  22. Gomez Morales MA, La Rosa G, Ludovisi A, Mochi Onori A, Pozio E. Cytokine profile induced by Cryptosporidium antigen in peripheral blood mononuclear cells from immunocompetent and immunosuppressed persons with cryptosporidiosis. Journal of infectious diseases 1999;179:967-973.
  23. Tosini F, Mele R, Gomez Morales MA, Cacciò SM, Tamburrini A, La Rosa G, Pozio E. Identification and characterization of three antigenic proteins from Cryptosporidium pervum sporozoites using a Dna library expressing poly-histidine tagged peptides. Roma: Istituto Superiore di Sanità; 1999. (Rapporti ISTISAN 99/11). p.372.
  24. Pozio E, Gomez Morales MA. Diagnosi sierologica delle infezioni parassitarie umane. Giornale italiano di malattie infettive 1998;4(1):7-15.
  25. Rossi P, La Rosa G, Ludovisi A, Tamburrini A, Gomez Morales MA, Pozio E. Identification of a human isolate of Encephalitozoon cuniculi type I from Italy. International journal for parasitology 1998;28(9):1361-1366.
  26. Gomez Morales MA, Ausiello CM, Guarino A, Urbani F, Spagnuolo MI, Pignata C, Pozio E. Severe and protracted intestinal cryptosporidiosis associated with interferon-gamma deficiency: a pediatric case. Pediatrics (Ed. italiana) 1998;1:18-19.
  27. Rossi P, La Rosa G, Ludovisi A, Tamburrini A, Gomez Morales MA, Pozio E. Identification of Encephalitozoon cuniculi type I isolated from a person with AIDS in Italy [abstract]. Parassitologia 1998;40(Suppl 1):158.
  28. Pozio E, Tamburrini A, Sacchi L, Gomez Morales MA, Corona S, Goffredo E, La Rosa G. Detection of Trichinella spiralis in a horse during routine examination in Italy. International journal for parasitology 1997;27(12):1613-1621.
  29. La Rosa G, Gomez Morales MA, Tamburrini A, Ludovisi A, Rossi P, Sacchi L, Pozio E. Isolation of a genomic region of encephalitozoon cuniculi (microsporidia) encoding an antigenic polypeptide [abstract]. Parassitologia 1996;38:162.
  30. Pozio E, Guarino A, Pignata C, Gomez Morales MA. Possible development of resistance to fluconazole during suppressive therapy for AIDS-associated cryptococcal meningitis (Letter). Clinical infectious diseases 1996;23:1337.
  31. Gomez Morales MA, Ausiello CM, Guarino A, Urbani F, Spagnuolo MI, Pignata C, Pozio E. Severe, protracted intestinal cryptosporidiosis associated with interferon gamma deficiency: pediatric case report. Clinical infectious diseases 1996;22(5):848-850.
  32. Gomez Morales MA, Ausiello CM, Urbani F, Pozio E. Crude extract and recombinant protein of Cryptosporidium parvum oocysts induce proliferation of human peripheral blood mononuclear cells in vitro. Journal of infectious diseases 1995;172(1):211-216.
  33. Andrews JRH, Bandi C, Pozio E, Gomez Morales MA, Ainsworth R, Abernethy D. Identification of trichinella pseudospirals from a human case using random aplified polymorphic DNA. American journal of tropical medicine and hygiene 1995;53(2):185-188.
  34. Gomez Morales MA, Atzori C, Ludovisi A, Rossi P, Scaglia M, Pozio E. Opportunistic and non-opportunistic parasites in HIV-positive and negative patients with diarrhoea in Tanzania. Tropical medicine and parasitology 1995;46(2):109-114.
  35. Gomez Morales MA, Ausiello CM, Urbani F, La Rosa G, Crisanti A, Pozio E. Caratterizzazione in vitro della risposta cellulo-mediata nella criptosporidiosi umana. Roma: Istituto Superiore di Sanità; 1994. (Rapporti ISTISAN 94/03). p.350.
  36. Rossi P, La Rosa G, Ludovisi A, Gomez Morales MA, Voglino MC, Donelli G, Pozio E. Identificazione di un possibile serbatoio della microsporidiosi umana e sviluppo di una diagnosi immunologica e molecolare. Roma: Istituto Superiore di Sanità; 1994. (Rapporti ISTISAN 94/03). p.351.
  37. Gomez Morales MA, Urbani F, Ausiello CM, Bellomo C, Varese P, Pagni P, Pozio E. Proliferation of human peripheral blood mononuclear cells induced by trichinella spiralis and trichinella britovi antigens.. In: Campbell CW, Pozio E, Bruschi F, ed. 8. International Conference on Trichinellosis. Proceedings; September 7-10, 1993; Orvieto . Roma: Istituto Superiore di Sanità; 1994. p.231-234.
  38. Virga A, Gomez Morales MA, Croppo G, Pozio E. Specificy of Elisa test in the diagnosis of equine trichinellosis. In: Campbell CW, Pozio E, Bruschi F, ed. 8. International Conference on Trichinellosis. Proceedings; September 7-10, 1993; Orvieto . Roma: Istituto Superiore di Sanità; 1994. p.387-390.
  39. Ranucci L, Muller H, La Rosa G, Reckmann I, Gomez Morales MA, Spano F, Pozio E, Crisanti A. Characterisation and immunolocalization of a Cryptosporidium protein containing repeated amino acid motifs. Infection and immunity 1993;61(6):2347-2356.
  40. Pozio E, Varese P, Gomez Morales MA, Croppo G, Pelliccia D, Bruschi F. Comparison of human trichinellosis caused by Trichinella spiralis and by Trichinella britovi. American journal of tropical medicine and hygiene 1993;48(4):568-575.
  41. Ausiello CM, Urbani F, Gessani S, Spagnoli GC, Gomez Morales MA, Cassone A. Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans. Infection and immunity 1993;61(10):4105-4111.
  42. Molinari A, Stringaro A, Crateri P, Ramoni C, Dupuis ML, Gomez Morales MA, Torosantucci A, Cassone A, Arancia G. Interaction of natural killer-lymphokine activated killer cells with the human pathogenic microorganism Candida albicans. Microscopia elettronica 1993;14(Suppl.2):451-452.
  43. Cassone A, Torosantucci A, Palma C, Gomez Morales MA, Ausiello CM, Djeu JY. Cell wall constituents of Candida albicans as biological response modifiers. In: Goldstein AL, Garaci E, ed. Combination therapies New York: Plenum Press; 1992. p.159-166.
  44. Pozio E, Gomez Morales MA, Mancini Barbieri F, La Rosa G. Cryptosporidium: different behaviour in calves of isolates of human origin. Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86:636-638.
  45. Gomez Morales MA, Pozio E, Groppo G. Serodiagnosis of cryptosporidiosis in Italian HIV-positive patients by means of an oocyst soluble antigen in an ELISA. Journal of infection 1992;25:229-236.
  46. Gomez Morales MA, Pozio E, Croppo G. Detection of Cryptosporidium circulating antigens in human and calf sera. Journal of protozoology 1991;38(6):182S-183S.
  47. Rossi P, Pozio E, Besse MG, Gomez Morales MA, La Rosa G. Experimental cryptosporidiosis in hamsters. Journal of clinical microbiology 1990;28(2):356-357.

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