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Personale dell'ISS

Marco Gabbianelli

Dirigente di ricerca
+39 06 4990 2412
Viale Regina Elena 299
00161 - Roma (I)
marco.gabbianelli@iss.it


Curriculum vitae

Direttore di Reparto MACA - Nuovi Biomarcatori ed Epidemiologia Clinica

Pubblicazioni

  1. Calzolari A, Deaglio S, Sposi NM, Petrucci E, Morsilli O, Gabbianelli M, Malavasi F, Testa U, Peschle C. Transferrin receptor 2 protein is not expressed in normal erythroid cells. Biochemical journal 2004;381(Pt 3):629-634.
  2. Guerriero R, Gabbianelli M, Parolini I, Samoggia P, Petrucci E, Sargiacomo M, Chelucci C, Testa U, Peschle C. Inhibition of TPO-induced MAPK activity increases polyploidization in human differentiating MK progenitor cells. In: 43. Annual Meeting of the American Society for Cell Biology. Abstracts; December 13-17, 2003; San Francisco. 2003.
  3. Coppola S, Narciso L, Pelosi E, Cerio AM, Morsilli O, Bonci D, Gabbianelli M, De Maria R, Testa U, Peschle C. KDR stimulation by VEGF promotes megakaryotyic differentation and maturation in normal and leukemic CD34+ hematopoietic progenitor cells [abstract]. Blood 2003;102(11):828a.
  4. Gabbianelli M, Testa U, Massa A, Morsilli O, Saulle E, Sposi NM, Petrucci E, Mariani G, Peschle C. HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low dose dexamethasone. Blood 2003;101(7):2826-32.
  5. Casella I, Feccia T, Chelucci C, Samoggia P, Castelli G, Guerriero R, Parolini I, Petrucci E, Pelosi E, Morsilli O, Gabbianelli M, Testa U, Peschle C. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor. Blood 2003;101(4):1316-1323.
  6. Sposi NM, Rossini A, Cianetti L, Pasquini L, Petrucci E, Saulle E, Morsilli O, Gabbianelli M, Testa U. Expression and function of NRAMP2 and ferroportin-1 genes during hemopoietic differentiation [abstract]. International journal of molecular medicine 2002;10(Suppl. 1):S85.
  7. Sposi NM, Rossini A, Cianetti L, Saulle E, Pasquini L, Petrucci E, Morsilli O, Gabbianelli M, Testa U. Expression of NRAMP2 and ferroportin-1 during normal hemopoiesis [abstract]. Hematology journal 2002;3(Suppl 1):183.
  8. Pelosi E, Valtieri M, Coppola S, Botta R, Gabbianelli M, Lulli V, Marziali G, Masella B, Muller R, Sgadari C, Testa U, Bonanno G, Peschle C. Identification of the hemangioblast in postnatal life. Blood 2002;100(9):3203-3208.
  9. Sposi NM, Rossini A, Cianetti L, Saulle E, Petrucci E, Gabbianelli M, Peschle C, Testa U. Pattern od ferroportin-1 and Nramp2 gene expression in normal hematopoiesis. In: 6. International Symposium on Predictive Oncology & Intervention Strategies. Cancer Detection and Prevention. Abstracts; February 9-12, 2002; Paris. Paris: ISPO; 2002. p.S-75.
  10. Saulle E, Testa U, Zeuner A, Morsilli O, Rossini A, Sposi NM, Peschle C, Gabbianelli M. Upmodulation of ID2 correlates with an enhanced gamma-globin expression in adult BFU-E culture induced with kit ligand and dexamethasone [abstract]. Hematology journal 2002;3(Suppl 1):58.
  11. Gabbianelli M, Massa A, Morsilli O, Saulle E, Sposi NM, Testa U, Peschle C. Reactivation of HbF synthesis in sigle cell adult BFU-E culture: synergistic effect of kit ligand and low dose dexamethasone [abstract]. Blood 2001;98(11 part 2):21b.
  12. Gabbianelli M, Testa U, Massa A, Pelosi E, Sposi NM, Riccioni R, Lucchetti L, Peschle C. Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate. Blood 2000;95(11):3555-3561.
  13. Sposi NM, Cianetti L, Tritarelli E, Pelosi E, Militi S, Barberi T, Gabbianelli M, Saulle E, Kuhn LC, Peschle C, Testa U. Mechanisms of differential transferrin receptor expression in normal hematopoiesis. European journal of biochemistry 2000;267(23):6762-6774.
  14. Grignani F, Valtieri M, Gabbianelli M, Gelmetti V, Botta R, Lucchetti L, Masella B, Morsilli O, Pelosi E, Samoggia P, Pelicci PG, Peschle C. PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood 2000;96(4):1531-1537.
  15. Valtieri M, Gabbianelli M, Montesoro E, Pelosi E, Samoggia P, Testa U, Peschle C. (1) Purificazione, caratterizzazione ed amplificazione in vitro di cellule staminali di sangue periferico adulto e sangue cordonale. (2) Espansione e differenziazione monolinea (eritroide, megacariocitica, granulocitica, monocitica) in coltura di progenitori purificati. In: Orlando M, ed. 1. Progetto di ricerca di "Sangue" (1998). Progress report. Roma: Istituto Superiore di Sanità; 1999. (Rapporti ISTISAN 99/09). p.301-306.
  16. Ziegler BL, Valtieri M, Almedia Porada G, De Maria R, Muller R, Masella B, Gabbianelli M, Casella I, Pelosi E, Bock T, Zanjani E, Peschle C. KDR receptor: a key marker defining hematopoietic stem cells. Science 1999;285:1553-1558.
  17. Ziegler BL, Muller R, Valtieri M, Lamping CP, Thomas CA, Gabbianelli M, Giesert C, Buhring HJ, Kanz L, Peschle C. Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level. Blood 1999;93(10):3355-3368.
  18. Valtieri M, Tocci A, Gabbianelli M, Luchetti L, Masella B, Vitelli L, Botta R, Testa U, Condorelli G, Peschle C. Enforced TAL-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program. Cancer research 1998;58(3):562-569.
  19. Valtieri M, Tocci A, Luchetti L, Masella B, Gabbianelli M, Botta R, Lulli V, Condorelli G, Testa U, Peschle C. Enforced TAL-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program [abstract]. Experimental hematology 1998;25(8):792.
  20. Montesoro E, Testa U, Gabbianelli M, Peschle C. Unilineage dendritic cell cultures generated by purified human hematopoietic progenitor cells. Advances in experimental medicine and biology 1997;3(417):139-143.
  21. Tocci A, Parolini I, Gabbianelli M, Testa U, Luchetti L, Samoggia P, Masella B, Russo G, Valtieri M, Peschle C. Dual action of retinoic acid on human embryonic/fetal hematopoiesis: blockade of primitive progenitor proliferation and shift from multipotent/erytroid/monocytic to granulocytic differentiation program. Blood 1996;88(8):2878-2888.
  22. Testa U, Fossati C, Samoggia P, Masciulli R, Mariani G, Hassan HJ, Sposi NM, Guerriero R, Rosato V, Gabbianelli M, Pelosi E, Valtieri M, Peschle C. Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors. Blood 1996;88(8):3391-3406.
  23. Hassan HJ, Guerriero R, Testa U, Gabbianelli M, Mattia G, Montesoro E, Macioce G, Pace A, Ziegler BL, Peschle C. Megakaryocyte growth and maturation from purified peripheral blood progenitors in unilineage serum-free liquid culture. In: Abraham et al., ed. Molecular biology of hematopoiesis. Vol. 5 New York: Plenum Press; 1996. p.445-452.
  24. Gabbianelli M, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Testa U, Lyman S, Peschle C. Multi-level effecs of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 1995;86(5):1661-1670.
  25. Gabbianelli M, Testa U, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Lyman S, Peschle C. Multi-level effects of flt3 ligand on human hematopoiesis expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors [abstract]. Acta haematologica 1995;93:144-145.
  26. Guerriero R, Testa U, Gabbianelli M, Mattia G, Montesoro E, Macioce G, Pace A, Ziegler BL, Hassan HJ, Peschle C. Unilineage magakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture. Blood 1995;86(10):3725-3736.
  27. Guerriero R, Testa U, Gabbianelli M, Mattia G, Montesoro E, Macioce G, Pace A, Ziegler BL, Hassan HJ, Peschle C. Unlineage magakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture. Blood 1995;86(10):3725-3736.
  28. Giampaolo A, Pelosi E, Valtieri M, Montesoro E, Sterpetti P, Samoggia P, Camagna A, Mastroberardino G, Gabbianelli M, Testa U. HOXB gene expression and function in differentiating purified hematopoietic progenitors. Stem cells 1995;13(Suppl 1):90-105.
  29. Montesoro E, Gabbianelli M, Pelosi E, Bulgarini D, Labbaye C, Fossati C, Giampaolo A, Valtieri M, Camagna A, Massa A, Testa U, Peschle C. Cellular and molecular mechanisms underlying early hematopoiesis. In: Abraham NG, Shadduck RK, Levine AS, Takaku F, ed. Molecular biology of haematopoiesis Andover: Intercept; 1994. p.269-291.
  30. Peschle C, Carè A, Chelucci C, Gabbianelli M, Giampaolo A, Hassan HJ, Montesoro E, Pelosi E, Testa U, Valtieri M. Purified hematopoietic stem and progenitors cells (HSCs/HPCs): a novel tool for basic and clinical research [abstract]. British journal of haematology 1994;87(1):103.
  31. Testa U, Valtieri M, Gabbianelli M, Pelosi E, Montesoro E, Martucci R, Parolini I, Massa A, Camagna A, Mastroberardino G, Peschle C. Purified human hematopoietic progenitors: a tool for analysis of cellular mechanisms in early hematopoiesis. In: Verna R, Shamoo A, ed. Biotechnology today Roma: Ares - Serano Symposia; 1994. p.215-226.
  32. Proietti E, Tritarelli E, Gabriele L, Testa U, Greco G, Pelosi E, Gabbianelli M, Belardelli F, Peschle C. Combined interleukin 1 beta/interleukin 2 treatment in mice: synergistic myelostimulatory activity and protection against cyclophosphamide-induced myelosuppression. Cancer research 1993;53(3):569-576.
  33. Peschle C, Gabbianelli M, Testa U, Pelosi E, Barberi T, Fossati C, Valtieri M, Leone L. C-kit ligand reactivates fetal hemoglobin synthesis in serum free culture of stringently purified normal adult burst-forming unit-erythroid. Blood 1993;81(2):328-336.
  34. Testa U, Pelosi E, Gabbianelli M, Fossati C, Campisi S, Isacchi G, Peschle C. Cascade transactivation of growth factor receptors in early human hematopoiesis. Blood 1993;81(6):1442-1456.
  35. Peschle C, Testa U, Valtieri M, Gabbianelli M, Pelosi E, Montesoro E, Sposi NM, Fossati C, Camagna A, Carè A. Stringently purified human hematopoietic progenitors/stem cells: analysis of cellular/molecular mechanisms underlying early hematopoiesis. Stem cells 1993;11(5):356-370.
  36. Sposi NM, Zon L, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH, Peschle C. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 1992;89(14):6353-6357.
  37. Testa U, Valtieri M, Carè A, Pelosi E, Gabbianelli M, Montesoro E, Sposi NM, Bulgarini D, Camagna A, Isacchi G, Peschle C. Cellular and molecular mechanisms in early hematopoietic differentiation. Leukemia 1992;6(Suppl.3):146S.
  38. Pelosi E, Testa U, Gabbianelli M, Valtieri M, Montesoro E, Samoggia P, Mastroberardino G, Isacchi G, Peschle C. Cellular and molecular studies on the early stages of human hematopoietic differentiation in culture of pure progenitors.. Leukemia 1992;6(Suppl.4):41-42.
  39. Peschle C, Valtieri M, Testa U, Pelosi E, Montesoro E, Gabbianelli M, Carè A, Bulgarini D, Mastroberardino G, Isacchi G. Pure haematopoietic progenitors: a new tool to investigate cellular/moleclar mechanisms underlying early haematopoiesis. In: Malavasi F, Cortese R, Albertini A, ed. European biotechnology today. The impact of basic sciences on diagnosis and therapy Andover: Intercept; 1992. p.109-112.
  40. Pelosi E, Gabbianelli M, Testa U, Montesoro E, Samoggia P, Valtieri M, Mastroberardino G, Camagna A, Isacchi G, Peschle C. Pure human haematopoietic progenitors: a tool for the analysis of the cellular and molecular basis of haematopoiesis. In: Abraham NG, Shadduck RK, Levine AS, Takaku F, ed. Molecular biology of haematopoiesis Andover: Intercept; 1992. p.291-307.
  41. Peschle C, Valtieri M, Schirò R, Hassan HJ, Chelucci C, Testa U, Pelosi E, Montesoro E, Gabbianelli M, Guerriero R, Mastroberardino G, Camagna A, Isacchi G. Trasferimento genico in cellule staminali ematopoietiche. In: 2. Congresso della Società italiana di ematologia sperimentale. Atti; 19-21 novembre 1992; Genova. 1992. p.61-65.
  42. Gabbianelli M, Valtieri M, Peschle C. La cellula staminale emopoietica umana, normale e leucemica. Haematologica 1991;76(Suppl.3):293-302.
  43. Sargiacomo M, Valtieri M, Gabbianelli M, Pelosi E, Testa U, Camagna A, Peschle C. Pure human hematopoietic progenitors: direct inhibitory effect of transforming growth factors-beta 1 and -beta 2. Annals of the New York Academy of Sciences 1991;628:84-91.
  44. Gabbianelli M, Pelosi E, Valtieri M, Scalzo S, Testa U, Peschle C. A model for reactivation of hemoglobin F synthesis in normal adult erythropoiesis. Scandinavian journal of gastroenterology 1990;612:196-206.
  45. Gabbianelli M, Boccoli G, Cianetti L, Russo G, Testa U, Peschle C. HLA expression in hemopoietic development. Class I and II antigens are induced in the definitive erythroid lineage and differentially modulated by fetal liver cytokines. Journal of immunology 1990;144(9):3354-60.
  46. Gabbianelli M, Sargiacomo M, Pelosi E, Testa U, Isacchi G, Peschle C. "Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor. Le Scienze 1990;249(4976):1561-1564.
  47. Gabbianelli M, Pelosi E, Labbaye C, Valtieri M, Testa U, Peschle C. Reactivation of HbF synthesis in normal adult erythroid bursts by IL-3. British journal of haematology 1990;74(1):114-117.

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